We have developed a carbonylative approach to the synthesis of diversely substituted 2-aroylbenzoate esters featuring a new protocol for the carbonylative coupling of aryl bromides with boronic acids and a new strategy to favour carbonylative over non-carbonylative reactions. Two different synthetic pathways – (i) the alkoxycarbonylation of 2-bromo benzophenones and (ii) the carbonylative Suzuki–Miyaura ...

Carbapenemases are enzymes able to hydrolyze the last resort b-lactam antibiotics (carbapenems), which are used for the treatment of infections caused by resistant bacteria. Carbapenemases are structurally and mechanistically classified into serine-b-lactamases (SBLs) and metallo-b-lactamases (MBLs). In order to combat the hydrolytic activity of these enzymes, combination therapy of b-lactam with ...

Solvents constitute the largest component for many chemical processes and substitution of nonrenewable solvents is a longstanding goal for green chemistry. Here, we show that Pd-catalyzed carbonylative couplings, such as carbonylative cross-couplings, aminocarbonylations, and alkoxycarbonylations, can be successfully realized using renewable solvents. The present research covers not only well-established ...

Objective: Synthesis of novel aromatic Lipoxin A4 lactone analogues. <p><p>Results: Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields, employing 2-deoxy-d-ribose as a chiral pool starting material and the classical E-selective Wittig olefnation.